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Stop Animal
Exploitation NOW!
S. A. E. N.
"Exposing the truth to wipe
out animal experimentation"
Government Grants Promoting Cruelty to Animals
University of California, Los Angeles, CA
JOAQUIN M. FUSTER - Primate Testing - 2006
Grant Number: 5R01MH072641-02
Project Title: INTEGRATIVE APPROACH TO CORTICAL COGNITIVE
NETWORKS
PI Information: PROFESSOR JOAQUIN M. FUSTER,
joaquinf@ucla.edu
Phone: (310) 825-0247 or (310) 825-5528
Abstract:
This project has two major objectives. The first is to identify
structural and functional properties of cognitive neuronal networks in
cortex of association (prefrontal and posterior parietal) during working
memory. The second objective is largely methodological: to substantiate
the coupling between neural activity and hemodynamic changes in working
memory.
Both objectives will be pursued in the monkey by the combined use of
four minimally invasive and behavior-compatible recording methods:
near-infrared spectroscopy (NIRS), surface field-potential (FP)
recording, local field-potential (LFP) recording, and unit-activity
recording. NIRS signals and surface FPs will be recorded simultaneously
with epidural probes. Unit activity and local field potentials (LFPs)
will also be recorded simultaneously by means of transdural
microelectrodes.
Based on certain assumptions of cognitive network architecture and
the spatial resolution of each method, the four methods will be used in
combination to test three specific hypotheses of neural activation and
hemodynamic change in the regions of interest during the performance of
two working-memory tasks, spatial delayed response (DR) and non-spatial
delayed matching to sample (DMS).
The analysis will focus on the neural and hemodynamic activity during
the retention of a sensory stimulus in working memory. NIRS, FP, and
unit data will be correlated with each of the variables most relevant to
the specific hypotheses to be tested: cortical location, stimulus or
memorandum, task, time of trial, and level of correct performance.
In the study of neural-hemodynamic coupling in cognitive function,
special emphasis will be placed on the correlations between NIRS signals
and electrical manifestations of cell discharge. These correlations are
expected to provide crucial information on the neuronal basis of
functional imaging signals, such as those obtained by BOLD fMRI, in
human cognition.
Thesaurus Terms:
brain mapping, cognition, parietal lobe /cortex, prefrontal lobe
/cortex, short term memory brain circulation, brain electrical activity,
electrical potential, hemodynamics, neural transmission, performance,
stimulus /response Macaca mulatta, behavioral /social science research
tag, infrared spectrometry, microelectrode
Institution: UNIVERSITY OF CALIFORNIA LOS ANGELES
Office of Research Administration, LOS ANGELES, CA 90095
Fiscal Year: 2006
Department: NONE
Project Start: 09-SEP-2005
Project End: 31-JUL-2010
ICD: NATIONAL INSTITUTE OF MENTAL HEALTH
IRG: COG
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To protest the inhumane use of animals in
this experiment
Please email: JOAQUIN M.
FUSTER, joaquinf@ucla.edu
or
Phone: (310) 825-0247 or (310) 825-5528 or
Mail to: Joaquin M. Fuster
UCLA Psychr & Biobehav Sci
BOX 951759, 760 Westwood Plaza,
38-159 Semel Institute
Los Angeles, CA 90095-1759
We would also love to know about your efforts with this
cause:
saen@saenonline.org
Return to Grants
Return to University of California, Los Angeles, CA
Return to Facility Reports and Information
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Rats, mice, birds, amphibians and other animals have
been excluded from coverage by the Animal Welfare Act. Therefore research
facility reports do not include these animals. As a result of this
situation, a blank report, or one with few animals listed, does not mean
that a facility has not performed experiments on non-reportable animals. A
blank form does mean that the facility in question has not used covered
animals (primates, dogs, cats, rabbits, guinea pigs, hamsters, pigs,
sheep, goats, etc.). Rats and mice alone are believed to comprise over 90%
of the animals used in experimentation. Therefore the majority of animals
used at research facilities are not even counted.
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