New data from the Centers for
Disease Control and Prevention (CDC) shows the rate of Americans developing
a rare red meat allergy from tick bites is rising.... The heating of the
climate is likely to increase the range of the ticks that trigger this
disease.
Image: AdobeStock_130912085-small
The Centers for Disease Control and Prevention (CDC) has made public new
data about the incidence of Alpha-gal syndrome (AGS), a potentially
life-threatening allergy to mammals’ flesh that is linked to the saliva of
the lone star tick. This potentially lethal red meat allergy may already
have impacted as many as 450,000 U.S. citizens.
Made public on July 28, 2023, the data issued by the CDC in two papers in
the Morbidity and Mortality Weekly Report number 30 shows that, between 2010
and 2022, there were more than 110,000 suspected cases of alpha-gal syndrome
identified. But, because its diagnosis requires a positive diagnostic test
and a clinical exam, it is estimated that between 96,000 and 450,000
Americans may have been affected since 2010.
One of the papers is titled “Geographic Distribution of Suspected Alpha-gal
Syndrome Cases — United States, January 2017–December 2022.” It concludes
that the number of suspected AGS cases in the United States has increased
substantially since 2010. The states with established populations of lone
star ticks have been impacted the most, although suspected AGS cases were
also identified in areas outside of this tick’s range. From 2017 to 2021,
the number of cases increased by about 15,000 per year.
What Causes this Red Meat Allergy?
AGS (also called alpha-gal allergy, red meat allergy, or tick bite meat
allergy) is a serious allergic condition some people experience after they
consume food or products containing alpha-gal (galactose-α-1,3-galactose), a
sugar molecule found in most mammals but not naturally found in humans.
After having been bitten by these ticks, some people may become ill after
consuming red meat, namely flesh from cows, rabbits, deer, sheep, etc. But,
it could also sicken those tick bite victims who consume animal products
like gelatin and dairy and certain pharmaceuticals.
Lone Star Tick
The evidence suggests that AGS is primarily associated with the bite of a
lone star tick (Amblyomma americanum), mostly found in southern and eastern
parts of the USA, but other kinds of ticks have not been ruled out. This
tick is identifiable by a white spot on the back.
The heating of the climate
is likely to increase the range of the ticks that trigger this disease,
placing more northern populations at risk.
Dr. Ann Carpenter, epidemiologist and lead author of one of the papers
released by the CDC, said in a press release, “It’s critical for clinicians
to be aware of AGS so they can properly evaluate, diagnose, and manage their
patients and also educate them on tick-bite prevention to protect patients
from developing this allergic condition.”
Dr. Johanna Salzer, senior author on the two CDC papers on this issue, said,
“The burden of alpha-gal syndrome in the United States could be substantial
given the large percentage of cases suspected to be going undiagnosed due to
non-specific and inconsistent symptoms, challenges seeking health care, and
lack of clinician awareness.”
“Alpha-gal syndrome is an important emerging public health problem, with
potentially severe health impacts that can last a lifetime for some
patients.” — Dr. Ann Carpenter, epidemiologist and author of one of the
study
Not Many Doctors Know about the Red Meat Allergy
One of the papers released by the CDC is titled “Health Care Provider
Knowledge Regarding Alpha-gal Syndrome — United States, March–May 2022.”
This one reports on a nationwide survey of health care providers (HCP) that
showed that 42% of the 1,500 respondents were not aware of AGS, and another
35% were not confident in their ability to diagnose or manage AGS patients.
Only 5% said they were “very confident” in their ability.
This result could be partly explained by the fact this syndrome was not
discovered until 2008, after US researchers found unexpected results while
testing a drug used to treat cancer. Also, because of how slowly the human
body digests meat, it can be very difficult to link the symptoms to red meat
consumption as they may not appear immediately after eating animal products.
The report states, “Limited HCP knowledge about AGS is concerning,
especially because the number of suspected cases is increasing, and the
range of the tick primarily associated with this condition is expected to
expand. Improved HCP education might facilitate a rapid diagnosis of AGS,
improve patient care, and support public health understanding of this
emerging condition.”
Alpha-gel syndrome Symptoms can vary from person to person and include
stomach cramps, diarrhea, hives and shortness of breath that could trigger
fatal anaphylaxis.
This meat allergy is not the only one that has been detected. The paralysis
tick (Ixodes holocyclus) has also caused similar meat allergies in Sydney,
Australia. It does seem that the best way to avoid this disease is to become
vegan, as vegans who are bitten by these dangerous ticks would not show any
allergic reaction as they do not consume any animal products containing
alpha-gal.
“It’s important that people who think they may suffer from AGS see their
healthcare provider or an allergist, provide a detailed history of symptoms,
get a physical examination, and a blood test that looks for specific
antibodies to alpha-gal.” —Dr. Johanna Salzer, senior author on the two CDC
papers.
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